I-CYANOCOBALAMIN (IVITAMIN B12)
Imilo kunye neempawu
Le mveliso yikristale ebomvu okanye i-crystalline powder, ayinavumba, ayinancasa kwaye ineempawu ezinamandla zokufunxa umswakama. Inyibilika kancinci emanzini okanye kwi-ethanol, ayinyibiliki kwi-chloroform okanye kwi-ether. Ayinakumelana nobushushu, kodwa isenokungasebenzi xa ivezwa kwizinto ezikhupha i-oxidizing okanye ezinciphisa ubushushu, iityuwa zesinyithi esinzima kunye nee-asidi ezinamandla kunye ne-alkalis ezinamandla.
Ulwakhiwo lweKhemikhali
I-Vitamin B12 yi-equioctaphedral compound equlethe ii-ion ze-cobalt. Ulwakhiwo lwayo oluphakathi yi-flat corrin ring eyenziwe zii-pyrroles ezine ezidityanisiweyo. Iimolekyuli ze-vitamin B12 zenziwe malunga neenxalenye ezi-3: i-gourin ring e-chylated yi-atoms ezine ze-N kunye nee-ion ze-cobalt eziphakathi; i-5,6-dimethylbenzimidazole edityaniswe nee-atoms ze-N-7 kunye nee-ion ze-cobalt njengeemolekyuli ze-vitamin B 12 zee-ligands ezisezantsi. Ukongeza, i-DMBI ikwadityaniswe ne-aminopropanol ngamaqela e-phosphate, kwaye i-aminopropanol idityaniswe ngokudibeneyo kwi-chain ye-propionic acid ecaleni kwi-pyrrole D; iqela le-adenosyl okanye iqela le-methyl. Idityaniswe nee-ion ze-cobalt ukwenza i-ligand ephezulu yeemolekyuli ze-vitamin B12.
Umsebenzi wePhysiological
Ukunqongophala kwevithamini B12 kunokukhokelela kwi-peripheral neuritis. Iimpawu zokuqala zokunqongophala kwevithamini B12 ebantwaneni ziimvakalelo ezingaqhelekanga, ukuziva kancinci, ukuphendula kancinci, kwaye ekugqibeleni kukhokelela kwi-anemia. Ukukhuthaza uphuhliso kunye nokuvuthwa kweeseli ezibomvu zegazi. I-Methylpropandiyl coenzyme A iguqulwa ibe yi-succinoyl coenzyme A kwaye ithatha inxaxheba kumjikelo we-tricarboxylic acid, apho i-succinyl coenzyme A inxulumene nokwenziwa kwe-heme. I-Vitamin B12 ikwathatha inxaxheba ekwenziweni kwe-deoxynucleic acid (DNA), imetabolism yamafutha, iicarbohydrate kunye neeproteni, kwaye yonyusa ukwenziwa kwe-nucleic acids kunye neeproteni.
